5-(3-Methylbenzyl)-2-thiouracil → 2-[2-(5-Methyl-4-imidazolylmethylthio)ethylamino]-5-(4-methylbenzyl)-4-pyrimidone dihydrochloride

HRID 237058Notes

Reaction equation

HRID 237058 reaction equation
[ClH:1].Cl.[CH3:3][C:4]1[NH:8][CH:7]=[N:6][C:5]=1[CH2:9][S:10][CH2:11][CH2:12][NH:13][C:14]1[NH:19][C:18](=[O:20])[C:17]([CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[C:24](C)[CH:23]=2)=[CH:16][N:15]=1.[CH3:29]C1C=C(C=CC=1)CC1C(=O)NC(=S)NC=1>>[ClH:1].[ClH:1].[CH3:3][C:4]1[NH:8][CH:7]=[N:6][C:5]=1[CH2:9][S:10][CH2:11][CH2:12][NH:13][C:14]1[NH:19][C:18](=[O:20])[C:17]([CH2:21][C:22]2[CH:23]=[CH:24][C:25]([CH3:29])=[CH:26][CH:27]=2)=[CH:16][N:15]=1

Participants

3

Reactant 2

HCID 100826715-(3-Methylbenzyl)-2-thiouracilHCID 233461802-[2-(5-Methyl-4-imidazolylmethylthio)ethylamino]-5-(3-methylbenzyl)-4-pyrimidone dihydrochloride

Product 1

HCID 233461972-[2-(5-Methyl-4-imidazolylmethylthio)ethylamino]-5-(4-methylbenzyl)-4-pyrimidone dihydrochloride

Procedure

In a similar manner 2-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]-5-(3-methylbenzyl)-4-pyrimidone dihydrochloride m.p. 203.5°-205° (ex ethanol) may be prepared from 5-(3-methylbenzyl)-2-thiouracil.

Sources & evidence

ORD record
ord-2d33e5c7285146a1a0b63e61f080f043
Source dataset
uspto-grants-1979_06
Patent number
US04159329

Reaction notes

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