Hydrochloric Acid → HCID 131711522, Verbindung

HRID 237060Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 237060
[Cl:1][C:2]1[CH:17]=[CH:16][C:5]([CH2:6][C:7]2[C:8](=[O:15])[NH:9][C:10](SC)=[N:11][CH:12]=2)=[CH:4][CH:3]=1.S1C=CN=C1CSCCN.Cl>>[ClH:1].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][C:7]2[C:8](=[O:15])[NH:9][CH:10]=[N:11][CH:12]=2)=[CH:16][CH:17]=1

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 129234032-[(Thiazol-2-yl)methylthio]ethylamineHCID 129459805-(4-Chlorobenzyl)-2-methylthiopyrimid-4-one

Produkt 1

HCID 131711522HCID 131711522, Verbindung

Versuchsvorschrift

An intimate mixture of 5-(4-chorobenzyl)-2-methylthio-4-pyrimidone (1.36 g) and 2-(2-thiazolylmethylthio)ethylamine (0.9 g) was heated at 130°-135° for 31/2 hours. After cooling the reaction mixture was treated with 2N hydrochloric acid. Evaporation to dryness followed by recrystallisation from isopropanol/methanol gave 2-[2-(2-thiazolyl-methylthio)ethylamino[-5-(4-chlorobenzyl)-4-pyrimidone monohydrochloride, m.p. 172.5°-174.5°.

Aufarbeitung

  1. temperaturewas heated at 130°-135° for 31/2 hours
  2. temperatureAfter cooling the reaction mixture
  3. customEvaporation to dryness
  4. customfollowed by recrystallisation from isopropanol/methanol

Quellen und Nachweise

ORD-Eintrag
ord-92bd9192a5284c3dbfd10917cb005965
Quelldatensatz
uspto-grants-1979_06
Patentnummer
US04159329

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