反应详情

A mixture of Example 1E (200.0 mg, 0.556 mmol), tert-butyl 4-aminobenzoate (129 mg, 0.667 mmol), and concentrated HCl (0.08 mL, 2.63 mmol) was heated at 160° C. for 30 minutes in a Biotage microwave reactor. The solvent was decanted. The remaining residue was treated with water, sonicated, filtered, washed with water, and oven-dried to provide the title compound as an HCl salt.

1. customThe solvent was decanted
2. additionThe remaining residue was treated with water
3. customsonicated
4. filtrationfiltered
5. washwashed with water
6. customoven-dried