Trifluoroacetic acid → HCID 68195150, compound

HRID 2370635Notes

Reaction equation

HRID 2370635 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[N:9]1[C:14](=[O:15])[C:13]2[CH:16]=[N:17][C:18]([NH:20][C:21]3[CH:30]=[C:29]4[C:24]([C:25]5([CH2:39][CH2:38]5)[CH2:26][N:27](C(OC(C)(C)C)=O)[CH2:28]4)=[CH:23][CH:22]=3)=[N:19][C:12]=2[N:11]2[CH:40]=[CH:41][N:42]=[C:10]12.C(O)(C(F)(F)F)=O>ClCCl>[Cl:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[C:3]=1[N:9]1[C:14](=[O:15])[C:13]2[CH:16]=[N:17][C:18]([NH:20][C:21]3[CH:30]=[C:29]4[C:24]([C:25]5([CH2:38][CH2:39]5)[CH2:26][NH:27][CH2:28]4)=[CH:23][CH:22]=3)=[N:19][C:12]=2[N:11]2[CH:40]=[CH:41][N:42]=[C:10]12

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68194913HCID 68194913, compound

Product 1

HCID 68195150HCID 68195150, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of Example 109A (0.12 g, 0.2 mmol) in 3 ml dichloromethane was added excess TFA. The reaction mixture was stirred at room temperature for one hour. The mixture was concentrated and the crude material was dried over high vacuum to provide the title compound. 1H NMR (300 MHz, DMSO-d6) δ 0.87-1.27 (m, 4H) 3.18-3.38 (m, 2H) 4.34-4.58 (m, 2H) 6.94 (d, J=8.48 Hz, 1H) 7.13 (d, J=1.70 Hz, 1H) 7.39-8.01 (m, 6H) 8.91-9.45 (m, 3H) 10.88 (s, 1H). MS (ESI+) m/z 504.2 (M+H)+.

Workup

  1. concentrationThe mixture was concentrated
  2. dry with materialthe crude material was dried over high vacuum

Sources & evidence

ORD record
ord-41cd964213e44cafb401c06b22e64112
Source dataset
uspto-grants-2014_04
Patent number
US08710065B2

Reaction notes

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