Potassium Carbonate → HCID 86670028, compound

HRID 2370659Notes

Reaction equation

HRID 2370659 reaction equation
[F:1][CH:2](F)[CH2:3]I.[CH3:6][C:7]1([CH3:18])[C:16]2[C:11](=[CH:12][C:13]([NH2:17])=[CH:14][CH:15]=2)[CH2:10][NH:9][CH2:8]1.BrCCF.C([O-])([O-])=O.[K+].[K+]>>[F:1][CH2:2][CH2:3][N:9]1[CH2:8][C:7]([CH3:6])([CH3:18])[C:16]2[C:11](=[CH:12][C:13]([NH2:17])=[CH:14][CH:15]=2)[CH2:10]1

Participants

5

Reactant 4

HCID 11430Potassium CarbonateHCID 129822-Fluoroethyl bromideHCID 38335651,1-Difluoro-2-iodoethaneHCID 590215334,4-Dimethyl-1,2,3,4-tetrahydroisoquinolin-7-amine

Product 1

HCID 86670028HCID 86670028, compound

Procedure

The title compound was prepared as described in Example 224B, substituting Example 224A and 1,1-difluoro-2-iodoethane with 4,4-dimethyl-1,2,3,4-tetrahydroisoquinolin-7-amine and 1-bromo-2-fluoroethane, respectively, and using 2.5 equivalent of K2CO3.

Sources & evidence

ORD record
ord-3739f900508f44468c459c910bdbdc5d
Source dataset
uspto-grants-2014_04
Patent number
US08710065B2

Reaction notes

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