Lawesson's reagent → HCID 88868299, compound

HRID 2370661Notes

Reaction equation

HRID 2370661 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:17](=O)[C:16]2[C:11](=[N:12][C:13]([S:19][CH3:20])=[N:14][CH:15]=2)[N:10]2[CH:21]=[CH:22][N:23]=[C:9]12.COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:33])=CC=1>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:17](=[S:33])[C:16]2[C:11](=[N:12][C:13]([S:19][CH3:20])=[N:14][CH:15]=2)[N:10]2[CH:21]=[CH:22][N:23]=[C:9]12

Participants

4

Reactant 2

HCID 87949Lawesson's reagentHCID 68194532HCID 68194532, compound

Product 1

HCID 88868299HCID 88868299, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A solution of Example 1D (0.730 g, 2.123 mmol) and Lawesson's reagent (0.515 g, 1.274 mmol) in toluene (40 mL) was heated to reflux for 4 hours. The reaction mixture was concentrated and purified on a 40 g column using the ISCO Companion flash system eluting with hexane/ethyl acetate (1:1 to 4:6) to provide the title compound.

Workup

  1. temperatureto reflux for 4 hours
  2. concentrationThe reaction mixture was concentrated
  3. custompurified on a 40 g column
  4. washeluting with hexane/ethyl acetate (1:1 to 4:6)

Sources & evidence

ORD record
ord-fe19e5120431411fadaae988fab5a4a5
Source dataset
uspto-grants-2014_04
Patent number
US08710065B2

Reaction notes

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