HCID 178454059, compound → HCID 178511693, compound

HRID 2370728Notes

Reaction equation

HRID 2370728 reaction equation
C(OC(=O)[NH:7][C@H:8]1[CH2:13][CH2:12][C@@H:11]([O:14][C:15]2[C:16]([Cl:25])=[C:17]3[C:22](=[CH:23][CH:24]=2)[CH:21]=[N:20][CH:19]=[CH:18]3)[CH2:10][CH2:9]1)(C)(C)C>C(O)C>[Cl:25][C:16]1[C:15]([O:14][C@@H:11]2[CH2:10][CH2:9][C@H:8]([NH2:7])[CH2:13][CH2:12]2)=[CH:24][CH:23]=[C:22]2[C:17]=1[CH:18]=[CH:19][N:20]=[CH:21]2

Participants

3

Reactant 1

HCID 178454059HCID 178454059, compound

Product 1

HCID 178511693HCID 178511693, compoundYield 100.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

50 mg (0.13 mmol) cis-[4-(5-Chloro-isoquinolin-6-yloxy)-cyclohexyl]carbamic acid tert-butyl ester (12) were dissolved in ethanol/2N HCl (1:1) and stirred at room temperature until complete conversion could be detected (LCMS). Evaporation of the solvent furnished 36 mg of the title compound as hydrochloride. Rt=0.71 min (Method #1). Detected mass: 277.2/279.2 (M+H+).

Workup

  1. customEvaporation of the solvent

Sources & evidence

ORD record
ord-6520a7053e1141a6ae409c793a561c88
Source dataset
uspto-grants-2014_04
Patent number
US08710228B2

Reaction notes

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