7-Chloro-6-fluoroisoquinoline → HCID 178454055, compound

HRID 2370740Notes

Reaction equation

HRID 2370740 reaction equation
ClC1C=C2C(C=CN=C2)=CC=1F.C(OC(=O)N[C@H]1CC[C@@H](O)CC1)(C)(C)C.[C:28]([O:32][C:33](=[O:53])[NH:34][C@H:35]1[CH2:40][CH2:39][C@H:38]([O:41][C:42]2[C:43]([Cl:52])=[C:44]3[C:49](=[CH:50][CH:51]=2)[CH:48]=[N:47][CH:46]=[CH:45]3)[CH2:37][CH2:36]1)([CH3:31])([CH3:30])[CH3:29]>>[C:28]([O:32][C:33](=[O:53])[NH:34][C@H:35]1[CH2:36][CH2:37][C@@H:38]([O:41][C:42]2[CH:51]=[C:50]3[C:49](=[CH:44][C:43]=2[Cl:52])[CH:48]=[N:47][CH:46]=[CH:45]3)[CH2:39][CH2:40]1)([CH3:29])([CH3:31])[CH3:30]

Participants

4

Reactant 3

HCID 534189227-Chloro-6-fluoroisoquinolineHCID 178418813HCID 178418813, compoundHCID 178454060HCID 178454060, compound

Product 1

HCID 178454055HCID 178454055, compound

Procedure

Starting with 7-chloro-6-fluoro-isoquinoline (6) and cis-(4-hydroxy-cyclohexyl)-carbamic acid tert-butyl ester, the title compound was prepared by the protocol described for trans-[4-(5-chloro-isoquinolin-6-yloxy)-cyclohexyl]-carbamic acid tert-butyl ester (10). Rt=1.07 min (Method #4). Detected mass: 377.2/379.2 (M+H+).

Sources & evidence

ORD record
ord-3f82a9a00f9a4891beb1189a9964cfaf
Source dataset
uspto-grants-2014_04
Patent number
US08710228B2

Reaction notes

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