6-Fluoroisoquinoline → HCID 57646988, compound

HRID 2370743Notes

Reaction equation

HRID 2370743 reaction equation
CO[CH:3](OC)[CH2:4][N:5]([CH2:16][C:17]1[CH:22]=[C:21]([F:23])[C:20]([F:24])=[C:19]([F:25])[CH:18]=1)S(C1C=CC(C)=CC=1)(=O)=O.FC1C=C2C(=CC=1)C=NC=C2>>[F:25][C:19]1[C:20]([F:24])=[C:21]([F:23])[CH:22]=[C:17]2[C:18]=1[CH:3]=[CH:4][N:5]=[CH:16]2

Participants

3

Reactant 2

HCID 218898476-FluoroisoquinolineHCID 59268525HCID 59268525, compound

Product 1

HCID 57646988HCID 57646988, compound

Procedure

Cyclisation of N-(2,2-dimethoxy-ethyl)-4-methyl-N-(3,4,5-trifluoro-benzyl)-benzene-sulfonamide (100) by the method described for 6-fluoro-isoquinoline (5) gave the desired isoquinoline, which was isolated as trifluoro acetate after final purification by prep. HPLC. Rt=1.15 min (Method #1). Detected mass: 184.0 (M+H+).

Sources & evidence

ORD record
ord-169b2ec061584f848101a3e6a3bb1aa8
Source dataset
uspto-grants-2014_04
Patent number
US08710228B2

Reaction notes

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