Methanol → HCID 178499561, compound

HRID 2370909Notes

Reaction equation

HRID 2370909 reaction equation
[NH:1]1[CH:5]=[C:4]([CH2:6][C:7]([OH:9])=[O:8])[N:3]=[CH:2]1.S(Cl)([Cl:12])=O.[CH3:14]O>>[ClH:12].[NH:1]1[CH:5]=[C:4]([CH2:6][C:7]([O:9][CH3:14])=[O:8])[N:3]=[CH:2]1

Participants

4

Reactant 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 96215Imidazole-4-acetic acid

Product 1

HCID 178499561HCID 178499561, compound

Procedure

5.0 g (30.75 mmol) of 4-imidazoleacetic acid were dissolved in 50 ml of methanol and then 5.6 ml (76.87 mmol) of thionyl chloride were added. The resulting solution was heated under reflux for 4 h and, after cooling, evaporated to dryness. Drying under reduced pressure afforded 5.3 g of the desired product in the form of a pale yellow solid.

Workup

  1. temperatureThe resulting solution was heated
  2. temperatureunder reflux for 4 h
  3. temperatureafter cooling
  4. customevaporated to dryness
  5. customDrying under reduced pressure

Sources & evidence

ORD record
ord-2bfba4ceb690482980b9731a87a1c3c9
Source dataset
uspto-grants-2014_04
Patent number
US08710232B2

Reaction notes

Loading…