5-(p-Fluorophenyl)-3-hydrazino-1,2,4-triazine → 7-(p-Fluorophenyl)-3-methyl-1,2,4-triazolo[4,3-b]-1,2,4-triazine

HRID 237091Notes

Reaction equation

HRID 237091 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]([NH:14][NH2:15])[N:11]=[N:12][CH:13]=2)=[CH:4][CH:3]=1.[C:16]([O-])([O-])(OCC)[CH3:17]>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:13]=[N:12][N:11]3[C:16]([CH3:17])=[N:15][N:14]=[C:10]3[N:9]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 127486495-(p-Fluorophenyl)-3-hydrazino-1,2,4-triazineHCID 86598186Ethyl ortho-acetate

Product 1

HCID 213152257-(p-Fluorophenyl)-3-methyl-1,2,4-triazolo[4,3-b]-1,2,4-triazine

Procedure

A mixture of 0.57 g. of 5-(p-fluorophenyl)-3-hydrazino-1,2,4-triazine and 20 ml. of ethyl orthoacetate is refluxed for 4 hours, cooled and filtered. The desired product is recovered as a brown solid, m.p. 227.5°-231° C.

Workup

  1. additionA mixture of 0.57 g
  2. temperaturecooled
  3. filtrationfiltered
  4. customThe desired product is recovered as a brown solid, m.p. 227.5°-231° C.

Sources & evidence

ORD record
ord-ef24a053df5940b8aa1d2965c95e8aba
Source dataset
uspto-grants-1979_06
Patent number
US04159375

Reaction notes

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