反应详情

1 ml of an HCl-saturated ether solution was added to a solution of 50.0 mg (0.16 mmol) of the compound from example 1i in 2 ml of cyclopropylcarbinol and stirred at room temperature for 12 h. The solution was then concentrated to dryness, and the resulting residue was dried under high vacuum. Purification by chromatography on silica gel with CH2Cl2/methanol as mobile phase afforded 29 mg of the title compound in the form of an amorphous solid.

1. concentrationThe solution was then concentrated to dryness
2. customthe resulting residue was dried under high vacuum
3. customPurification by chromatography on silica gel with CH2Cl2/methanol as mobile phase