Methanol → 3-Hydrazino-5-(alpha,alpha,alpha-trifluoro-m-tolyl)-1,2,4-triazine

HRID 237094Notes

Reaction equation

HRID 237094 reaction equation
CS[C:3]1[N:4]=[N:5][CH:6]=[C:7]([C:9]2[CH:10]=[C:11]([C:15]([F:18])([F:17])[F:16])[CH:12]=[CH:13][CH:14]=2)[N:8]=1.CO.[NH2:21][NH2:22]>O1CCCC1>[NH:21]([C:3]1[N:4]=[N:5][CH:6]=[C:7]([C:9]2[CH:10]=[C:11]([C:15]([F:18])([F:17])[F:16])[CH:12]=[CH:13][CH:14]=2)[N:8]=1)[NH2:22]

Participants

5

Reactant 3

HCID 887MethanolHCID 9321HydrazineHCID 3053026as-Triazine, 3-(methylthio)-5-(alpha,alpha,alpha-trifluoro-m-tolyl)-

Product 1

HCID 30530543-Hydrazino-5-(alpha,alpha,alpha-trifluoro-m-tolyl)-1,2,4-triazine

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 22.8 g. of 3-methylthio-5-(α,α,α-trifluoro-m-tolyl)-1,2,4-triazine in a mixture of 30 ml. of methanol and 35 ml. of tetrahydrofuran is added 4.84 ml. of 95% hydrazine. The mixture is refluxed for 48 hours, cooled and the solid is collected by filtration giving 3-hydrazino-5-(α,α,α-trifluoro-m-tolyl)-1,2,4-triazine as yellow needles.

Workup

  1. temperatureThe mixture is refluxed for 48 hours
  2. temperaturecooled
  3. filtrationthe solid is collected by filtration

Sources & evidence

ORD record
ord-7ed030818d0e4b6199eecbd3e47c4e91
Source dataset
uspto-grants-1979_06
Patent number
US04159375

Reaction notes

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