Hydrazine hydrate (1:1) → 6-(4-Fluorophenyl)-3-hydrazinyl-1,2,4-triazine

HRID 237097Notes

Reaction equation

HRID 237097 reaction equation
Cl[C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=2)=[CH:6][N:7]=1.O.[NH2:16][NH2:17]>N1C=CC=CC=1>[NH:16]([C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=2)=[CH:6][N:7]=1)[NH2:17]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 213152193-Chloro-6-(4-fluorophenyl)-1,2,4-triazine

Product 1

HCID 213152186-(4-Fluorophenyl)-3-hydrazinyl-1,2,4-triazine

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A solution of 9.8 g. of 3-chloro-6-(p-fluorophenyl)-1,2,4-triazine in 125 ml. of pyridine is cooled to 0° C. and 15 ml. of hydrazine hydrate is added. The mixture is stirred at room temperature for one hour and then poured into icewater. The solid is recovered by filtration and washed with ethanol, giving 3-hydrazino-6-(p-fluorophenyl)-1,2,4-triazine as an orange solid.

Workup

  1. additionpoured into icewater
  2. filtrationThe solid is recovered by filtration
  3. washwashed with ethanol

Sources & evidence

ORD record
ord-c279d885aaa140f9bb11cee7ab004c31
Source dataset
uspto-grants-1979_06
Patent number
US04159375

Reaction notes

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