反应详情

To a solution of ethyl 3-(thiophen-3-yl)acrylate (5 g, 27.5 mmol) in CH3NO2 (20 mL) was added Triton B (5 mL) under N2 and the resulting reaction mixture was refluxed overnight. The reaction mixture was concentrated and then diluted with water. The mixture was extracted with EtOAc, washed with brine, and dried over anhydrous Na2SO4. After filtration and concentration, the crude product was purified by column chromatography to give the title compound (4.3 g, 65%).

1. customthe resulting reaction mixture
2. temperaturewas refluxed overnight
3. concentrationThe reaction mixture was concentrated
4. additiondiluted with water
5. extractionThe mixture was extracted with EtOAc
6. washwashed with brine
7. dry with materialdried over anhydrous Na2SO4
8. filtrationAfter filtration and concentration
9. customthe crude product was purified by column chromatography