反应详情

To a solution of ethyl 4-nitro-3-(thiophen-3-yl)butanoate (4.3 g, 18.2 mmol) in MeOH (40 mL) at 0° C. was added 3 N aqueous NaOH (10 mL). The resulting mixture was stirred at room temperature overnight. 2 N HCl was then added to adjust pH to 3˜4 followed by extraction with DCM. The organic extract was washed with brine and dried over anhydrous Na2SO4. After filtration, the solution was concentrated to give the title compound (3.4 g, 87%).

1. extractionfollowed by extraction with DCM
2. extractionThe organic extract
3. washwas washed with brine
4. dry with materialdried over anhydrous Na2SO4
5. filtrationAfter filtration
6. concentrationthe solution was concentrated