反应详情

To a solution of 4-nitro-3-(thiophen-3-yl)butanoic acid (3.4 g, 15.9 mmol) in DCE (20 mL) was added PPA (20 g) and the resulting mixture was refluxed overnight. After concentration, the reaction mixture was treated with solid NaOH, followed by addition of water. After stirring for 30 minutes, the mixture was extracted with DCM. The DCM extract was washed with brine and dried over anhydrous Na2SO4. After filtration and concentration, the crude product was purified by column chromatography to give the title compound (2.3 g, 74%).

1. temperaturethe resulting mixture was refluxed overnight
2. concentrationAfter concentration
3. additionthe reaction mixture was treated with solid NaOH
4. additionfollowed by addition of water
5. extractionthe mixture was extracted with DCM
6. extractionThe DCM extract
7. washwas washed with brine
8. dry with materialdried over anhydrous Na2SO4
9. filtrationAfter filtration and concentration
10. customthe crude product was purified by column chromatography