Hydrazine hydrate (1:1) → 6-(o-Fluorophenyl)-3-hydrazino-1,2,4-triazine

HRID 237104Notes

Reaction equation

HRID 237104 reaction equation
Cl[C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[F:14])=[CH:6][N:7]=1.O.[NH2:16][NH2:17]>N1C=CC=CC=1>[F:14][C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=1[C:5]1[N:4]=[N:3][C:2]([NH:16][NH2:17])=[N:7][CH:6]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 213152223-Chloro-6-(o-fluorophenyl)-1,2,4-triazine

Product 1

HCID 125812906-(o-Fluorophenyl)-3-hydrazino-1,2,4-triazine

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Conditions

Temperature
60 °C

Procedure

A 17.9 g. portion of 3-chloro-6-(o-fluorophenyl)-1,2,4-triazine is dissolved in 120 ml. of pyridine and cooled in an ice bath. An 8.5 g. portion of hydrazine hydrate is added and the mixture is heated at 60° C. for one hour and then cooled, poured into ice water and filtered giving 6-(o-fluorophenyl)-3-hydrazino-1,2,4-triazine as yellow plates.

Workup

  1. temperaturecooled
  2. filtrationfiltered

Sources & evidence

ORD record
ord-ef0937981a834ac2acc1ff3c96433fc0
Source dataset
uspto-grants-1979_06
Patent number
US04159375

Reaction notes

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