Ammonium Chloride → HCID 53239410, compound

HRID 2371043Notes

Reaction equation

HRID 2371043 reaction equation
[N+:1]([CH2:4][CH:5]1[C:14]2[CH:15]=[CH:16][S:17][C:13]=2[C:12]2[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=2[O:6]1)([O-])=O.[NH4+].[Cl-]>CC(O)=O.[Fe]>[S:17]1[C:13]2[C:12]3[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=3[O:6][CH:5]([CH2:4][NH2:1])[C:14]=2[CH:15]=[CH:16]1

Participants

5

Reactant 2

HCID 25517Ammonium ChlorideHCID 67258010HCID 67258010, compound

Product 1

HCID 53239410HCID 53239410, compoundYield 96%

Reagents, catalysts & solvents 2

HCID 23925IronCatalystHCID 176Acetic AcidSolvent

Procedure

To a solution of 4-(nitromethyl)-4H-thieno[3,2-c]chromene (2.5 g, 10.7 mmol) in AcOH (20 mL) was added NH4Cl (5.4 g, 100 mmol) and Fe (2.8 g, 50 mmol). After stirring overnight, the reaction mixture was filtered. The filtrate was concentrated under reduced pressure and the residue was purified by column chromatography to give the title compound (2.2 g, 96%).

Workup

  1. filtrationthe reaction mixture was filtered
  2. concentrationThe filtrate was concentrated under reduced pressure
  3. customthe residue was purified by column chromatography

Sources & evidence

ORD record
ord-c14a4458d35d469fb433d80bca77de07
Source dataset
uspto-grants-2014_04
Patent number
US08710245B2

Reaction notes

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