反应详情

To a solution of ethanethioamide (0.75 g, 10 mmol) in ethanol (20 mL) at room temperature was added 2-bromocyclohexane-1,3-dione (1.9 g, 10 mmol) in portions. The reaction solution was refluxed for 2 hours while stirring. After removal of solvents, the residue was diluted with water and washed with diethyl ether. The separated aqueous layer was basified with sodium carbonate solution. The resulting solid was collected by vacuum filtration, rinsed with water. The solid was suspended in methanol and followed by evaporation to dryness to produce the title compound.

1. temperatureThe reaction solution was refluxed for 2 hours
2. customAfter removal of solvents
3. additionthe residue was diluted with water
4. washwashed with diethyl ether
5. filtrationThe resulting solid was collected by vacuum filtration
6. washrinsed with water
7. customfollowed by evaporation to dryness