Hydrochloric Acid → HCID 86653070, compound

HRID 2371065Notes

Reaction equation

HRID 2371065 reaction equation
[C:1]([C:3]1[CH:4]=[CH:5][C:6]2[O:10][C:9]([C:11]([NH:13][CH:14]([C:19]3[CH:24]=[CH:23][CH:22]=[C:21]([C:25]([F:28])([F:27])[F:26])[CH:20]=3)[C:15]([F:18])([F:17])[F:16])=[O:12])=[CH:8][C:7]=2[CH:29]=1)#[N:2].Cl>CO.[Pd]>[NH2:2][CH2:1][C:3]1[CH:4]=[CH:5][C:6]2[O:10][C:9]([C:11]([NH:13][CH:14]([C:19]3[CH:24]=[CH:23][CH:22]=[C:21]([C:25]([F:28])([F:26])[F:27])[CH:20]=3)[C:15]([F:16])([F:17])[F:18])=[O:12])=[CH:8][C:7]=2[CH:29]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 86653071HCID 86653071, compound

Product 1

HCID 86653070HCID 86653070, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of 5-cyano-N-{2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethyl}-1-benzofuran-2-carboxamide (273 mg, 0.66 mmol) in methanol (10 ml) was admixed with concentrated hydrochloric acid (0.42 ml) and palladium on carbon (10%; 50 mg) and stirred under a hydrogen atmosphere for 2 h. The reaction mixture was then filtered through Celite® and a silica gel pad.

Workup

  1. filtrationThe reaction mixture was then filtered through Celite®

Sources & evidence

ORD record
ord-bc8dbd0c0dd945f2b326f95d9e354313
Source dataset
uspto-grants-2014_04
Patent number
US08710242B2

Reaction notes

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