Hydrazine hydrate (1:1) → HCID 12581291, compound

HRID 237109Notes

Reaction equation

HRID 237109 reaction equation
Cl[C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:9]=[C:10]([C:14]([F:17])([F:16])[F:15])[CH:11]=[CH:12][CH:13]=2)=[CH:6][N:7]=1.O.[NH2:19][NH2:20]>N1C=CC=CC=1>[NH:19]([C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:9]=[C:10]([C:14]([F:17])([F:16])[F:15])[CH:11]=[CH:12][CH:13]=2)=[CH:6][N:7]=1)[NH2:20]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 21315224HCID 21315224, compound

Product 1

HCID 12581291HCID 12581291, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Conditions

Temperature
60 °C

Procedure

A solution of 5.1 g. of 3-chloro-6-(α,α,α-trifluoro-m-tolyl)-1,2,4-triazine in 30 ml. of pyridine is cooled to 0° C. and 3.5 ml. of hydrazine hydrate is added. The mixture is heated to 60° C., maintained at 60° C. for one hour, cooled and poured into ice-water. The resulting slurry is filtered and the solid is washed with ethanol giving 3-hydrazino-6-(α,α,α-trifluoro-m-tolyl)-1,2,4-triazine as a yellow solid.

Workup

  1. temperaturemaintained at 60° C. for one hour
  2. temperaturecooled
  3. filtrationThe resulting slurry is filtered
  4. washthe solid is washed with ethanol

Sources & evidence

ORD record
ord-5f63ba865e7348e49c26a5fc7ed8c9d6
Source dataset
uspto-grants-1979_06
Patent number
US04159375

Reaction notes

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