Trifluoroacetic acid → HCID 11525056, compound

HRID 2371100Notes

Reaction equation

HRID 2371100 reaction equation
[C:1]1([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[CH:6]=[CH:5][C:4]([CH2:7][CH2:8][CH:9]([OH:31])[CH:10]([CH2:18][CH2:19][N:20]2[C:25](=[O:26])[C:24]3[CH:27]=[CH:28][CH:29]=[CH:30][C:23]=3[N:22]=[N:21]2)[C:11]([O:13]C(C)(C)C)=[O:12])=[CH:3][CH:2]=1.FC(F)(F)C(O)=O>ClCCl>[C:1]1([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[CH:2]=[CH:3][C:4]([CH2:7][CH2:8][CH:9]([OH:31])[CH:10]([CH2:18][CH2:19][N:20]2[C:25](=[O:26])[C:24]3[CH:27]=[CH:28][CH:29]=[CH:30][C:23]=3[N:22]=[N:21]2)[C:11]([OH:13])=[O:12])=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 69245219HCID 69245219, compound

Product 1

HCID 11525056HCID 11525056, compoundYield 45.1%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of the compound (100 mg) obtained from step 3 above in dichloromethane (2 ml) at 0° C. was added trifluoroacetic acid (8 ml) and stirred the reaction mixture for about 2-3 hours and then at room temperature for 3 hours. The solvent and excess reagents were evaporated under reduced pressure and the residue thus obtained was purified by preparative thin layer chromatography (eluant-ethyl acetate) to furnish the title compound (40 mg).

Workup

  1. waitat room temperature for 3 hours
  2. customThe solvent and excess reagents were evaporated under reduced pressure
  3. customthe residue thus obtained
  4. customwas purified by preparative thin layer chromatography (eluant-ethyl acetate)

Sources & evidence

ORD record
ord-9e8a5e94a0a941dba15e915286d63b18
Source dataset
uspto-grants-2014_04
Patent number
US08710261B2

Reaction notes

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