3,4-Dichlorophenyl isocyanate → HCID 11538563, compound

HRID 2371121Notes

Reaction equation

HRID 2371121 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([N:9]=[C:10]=[O:11])[CH:5]=[CH:6][C:7]=1[Cl:8].[N:12]1([CH2:18][CH2:19][CH2:20][N:21]2[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]2)[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1>CN(C=O)C.ClCCl>[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]([N:24]2[CH2:23][CH2:22][N:21]([CH2:20][CH2:19][CH2:18][N:12]3[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17]3)[CH2:26][CH2:25]2)=[O:11])[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

5

Reactant 2

HCID 76073,4-Dichlorophenyl isocyanateHCID 27372531-(3-Piperidinopropyl)piperazine

Product 1

HCID 11538563HCID 11538563, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 6344DichloromethaneSolvent

Procedure

A solution of 3,4-dichlorophenylisocyanate (0.3 g; 1.5 mmol) in a mixture of DMF (0.5 ml) and dichloromethane (5 ml) was added to 1-(3-piperidinopropyl)-piperazine (0.21 g; 1 mmol) at room temperature. The resulting mixture was stirred at room temperature overnight.

Sources & evidence

ORD record
ord-b7cd6b51db4a4d0a9823d2889d255bcf
Source dataset
uspto-grants-2014_04
Patent number
US08710224B2

Reaction notes

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