Hydrochloric Acid → HCID 131711524, compound

HRID 237113Notes

Reaction equation

HRID 237113 reaction equation
[Cl:1][C:2]1[C:7]([CH2:8][O:9][CH:10]([C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=2)[CH2:11][N:12]2[CH:16]=[CH:15][N:14]=[CH:13]2)=[CH:6][N:5]=[C:4]2[N:24]([CH2:28][CH3:29])[N:25]=[C:26]([CH3:27])[C:3]=12.Cl>CCOCC>[ClH:1].[Cl:1][C:2]1[C:7]([CH2:8][O:9][CH:10]([C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=2)[CH2:11][N:12]2[CH:16]=[CH:15][N:14]=[CH:13]2)=[CH:6][N:5]=[C:4]2[N:24]([CH2:28][CH3:29])[N:25]=[C:26]([CH3:27])[C:3]=12

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21315235HCID 21315235, compound

Product 1

HCID 131711524HCID 131711524, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

To 5.4 g. of this product, 4-chloro-5-[[1-(4-chlorophenyl)-2-(1H-imidazol-1-yl)ethoxy]methyl]-1-ethyl-3-methyl-1H-pyrazolo[3,4-b]pyridine dissolved in 15 ml. of absolute alcohol and 5 ml. of alcoholic hydrochloric acid (184 g. HCl/l) by slight warming, are added 120 ml. of ether. The precipitated hydrochloride is filtered off after standing overnight, washed with a mixture of ether and alcohol (5:1) and dried, yield 6.3 g. (100%); m.p. 184°-185°.

Workup

  1. filtrationThe precipitated hydrochloride is filtered off
  2. washwashed with a mixture of ether and alcohol (5:1)
  3. customdried

Sources & evidence

ORD record
ord-6a9b1eb65b26461da182949f3b3fc425
Source dataset
uspto-grants-1979_06
Patent number
US04159380

Reaction notes

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