反应详情

4-(4,6-Dimethoxy[1.3.5]triazin-2-yl)-4-methylmorpholinium chloride hydrate (253 mg, Acros chemicals) was added to a solution of (2R)-1-(tert-butoxycarbonyl)-4-ethylpiperazine-2-carboxylic acid (212 mg) in dry dichloromethane (6 ml) followed by addition on N-methyl morpholine (0.28 ml) and stirring under argon for 1 h. piperazine (234 mg) was then added and stirring was continued for 18 h. Dichloromethane (30 ml) was added and extracted with 1M NaOH (2×10 mL). The organic layer was dried (MgSO4), filtered and evaporated. Purification by chromatography (5-50% MeOH:DCM) afforded the title compound (135 mg) as a foam.

1. additionfollowed by addition on N-methyl morpholine (0.28 ml)
2. additionwas then added
3. extractionextracted with 1M NaOH (2×10 mL)
4. dry with materialThe organic layer was dried (MgSO4)
5. filtrationfiltered
6. customevaporated
7. customPurification by chromatography (5-50% MeOH:DCM)