HRID2371268

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6422

未命名化合物

结构：CN(c1ccc(C(=O)OC(C)(C)C)cc1)C(C(=O)N(c1ccccc1)c1ccc2cccc-2o1)c1ccc(C(C)(C)C)cc1

HCID67486638

未命名化合物

PRODUCTS

生成物

结构：CN(c1ccc(C(=O)O)cc1)C(C(=O)N(c1ccccc1)c1ccc2cccc-2o1)c1ccc(C(C)(C)C)cc1

HCID67486026

未命名化合物

收率 108.7%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

4-{[(4-Benzofuran-2-yl-phenylcarbamoyl)-(4-tert-butyl-phenyl)-methyl]-methyl-amino}-benzoic acid tert-butyl ester (˜140 mg, 0.19 mmol) was taken up in 5 mL of dichloromethane followed by addition of 0.5 mL of TFA and stirred for 16 h at RT. Removal of the organic layer and water was added to give a precipitate, which was filtered to give 110 mg (100%) of pinkish solids. LCMS (M−1=531.1).

WORKUP

后处理

customRemoval of the organic layer and water
additionwas added
customto give a precipitate, which
filtrationwas filtered

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f4368d62d6a347cc92d61658b2bd96e9
来源数据集: uspto-grants-2014_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08710236B2
来源说明: uspto-grants-2014_04

反应 SMILES

C([O:5][C:6](=[O:44])[C:7]1[CH:12]=[CH:11][C:10]([N:13]([CH:15]([C:26](=[O:43])[N:27]([C:34]2[O:42][C:38]3=[CH:39][CH:40]=[CH:41][C:37]3=[CH:36][CH:35]=2)[C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[C:16]2[CH:21]=[CH:20][C:19]([C:22]([CH3:25])([CH3:24])[CH3:23])=[CH:18][CH:17]=2)[CH3:14])=[CH:9][CH:8]=1)(C)(C)C.C(O)(C(F)(F)F)=O>ClCCl>[O:42]1[C:38]2=[CH:39][CH:40]=[CH:41][C:37]2=[CH:36][CH:35]=[C:34]1[N:27]([C:28]1[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=1)[C:26]([CH:15]([N:13]([CH3:14])[C:10]1[CH:9]=[CH:8][C:7]([C:6]([OH:44])=[O:5])=[CH:12][CH:11]=1)[C:16]1[CH:17]=[CH:18][C:19]([C:22]([CH3:25])([CH3:23])[CH3:24])=[CH:20][CH:21]=1)=[O:43]