HCID 178444255, compound → HCID 178444256, compound

HRID 2371341Notes

Reaction equation

HRID 2371341 reaction equation
[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([CH:9]=[CH:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]3[CH:22]=[CH:21][C:20]([C@H:23]4[CH2:28][CH2:27][C@H:26]([CH2:29][CH2:30][CH2:31][CH2:32][CH3:33])[CH2:25][CH2:24]4)=[CH:19][C:18]=3[F:34])=[CH:13][CH:12]=2)=[CH:5][CH:4]=1)[CH3:2]>O1CCCC1.[Pd]>[CH2:1]([C:3]1[CH:4]=[CH:5][C:6]([CH2:9][CH2:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]3[CH:22]=[CH:21][C:20]([C@H:23]4[CH2:24][CH2:25][C@H:26]([CH2:29][CH2:30][CH2:31][CH2:32][CH3:33])[CH2:27][CH2:28]4)=[CH:19][C:18]=3[F:34])=[CH:13][CH:12]=2)=[CH:7][CH:8]=1)[CH3:2]

Participants

4

Reactant 1

HCID 178444255HCID 178444255, compound

Product 1

HCID 178444256HCID 178444256, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

A solution of 3.2 g of 1-(p-ethylphenyl)-2-[4'-(trans-4-n-pentylcyclohexyl)-2'-fluorobiphenyl-4-yl]ethene [obtained by Heck coupling of p-ethylstyrene with 4'-(trans-4-n-pentylcyclohexyl)-2'-fluoro-4-bromobiphenyl] in 100 ml of tetrahydrofuran is hydrogenated in the presence of Pd/C. Customary work-up gives 1-(p-ethylphenyl)-2-[4'-(trans-4-n-pentylcyclohexyl)-2'-fluorobiphenyl-4-yl)ethane.

Sources & evidence

ORD record
ord-27899417854a49fab1ec2d357b8f016f
Source dataset
uspto-grants-1992_03
Patent number
US05093026

Reaction notes

Loading…