HCID 57088222, compound → HCID 19906964, compound

HRID 2371342Notes

Reaction equation

HRID 2371342 reaction equation
[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([CH:9]=[CH:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]3[CH:22]=[CH:21][C:20]([CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])=[CH:19][C:18]=3[F:28])=[CH:13][CH:12]=2)=[CH:5][CH:4]=1)[CH3:2]>O1CCCC1.[Pd]>[CH2:1]([C:3]1[CH:4]=[CH:5][C:6]([CH2:9][CH2:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]3[CH:22]=[CH:21][C:20]([CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])=[CH:19][C:18]=3[F:28])=[CH:13][CH:12]=2)=[CH:7][CH:8]=1)[CH3:2]

Participants

4

Reactant 1

HCID 57088222HCID 57088222, compound

Product 1

HCID 19906964HCID 19906964, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

A solution of 1.2 g of 1-(p-ethylphenyl)-2-[4'-pentyl-2'-fluorobiphenyl-4-yl]ethene [obtained by Heck coupling of p-ethyl styrene with 4'-n-pentyl-2'-fluoro-4-bromobiphenyl] in 50 ml of tetrahydrofuran is hydrogenated in the presence of Pd/C. Customary work-up gives 1-(p-ethylphenyl)-2-(4'-n-pentyl-2'-fluorobiphenyl-4-yl)ethane.

Sources & evidence

ORD record
ord-11adda564cd64dde834a605d201440c9
Source dataset
uspto-grants-1992_03
Patent number
US05093026

Reaction notes

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