Hydrochloric Acid → Methyl N'-1,3,4-thiadiazol-2-ylcarbamimidothioate
Reaction equation
[S:1]1[CH:5]=[N:4][N:3]=[C:2]1[NH:6][C:7]([NH2:9])=[S:8].Cl.[CH2:11](O)C>[OH-].[Na+].CI>[S:1]1[CH:5]=[N:4][N:3]=[C:2]1[N:6]=[C:7]([S:8][CH3:11])[NH2:9]Participants
6
Conditions
- Temperature
- 40 °C
Procedure
A mixture of 4.8 g of 1,3,4-thiadiazol-2-ylthiourea (from Example 1B) in 45 ml of lN sodium hydroxide, 15 ml of ethanol and 4 ml of methyl iodide was heated at 40° C for ten minutes. The mixture was acidified by adding 50 ml of lN hydrochloric acid. The reaction mixture was concentrated by evaporation under reduced pressure. The precipitated solid was collected by filtration and dried to give 3.02 g of N'-1,3,4-thiadiazol-2-ylcarbamimidothioic acid, methyl ester. m.p. 116-117° C.
Workup
- concentrationThe reaction mixture was concentrated by evaporation under reduced pressure
- filtrationThe precipitated solid was collected by filtration
- customdried
Sources & evidence
- ORD record
- ord-8de1d0d24abb4d3fbd41bc9b0e0fd9b5
- Source dataset
- uspto-grants-1992_03
- Patent number
- US05093324
Reaction notes
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