Pyridine → HCID 14127620, compound

HRID 2371431Notes

Reaction equation

HRID 2371431 reaction equation
[NH2:1][C:2]1[CH:18]=[CH:17][CH:16]=[CH:15][C:3]=1[O:4][C:5]1[CH:6]=[CH:7][CH:8]=[C:9]2[C:14]=1[N:13]=[CH:12][CH:11]=[CH:10]2.[Cl:19][C:20]1[CH:25]=[CH:24][C:23]([S:26](Cl)(=[O:28])=[O:27])=[CH:22][CH:21]=1.N1C=CC=CC=1>ClCCl>[N:13]1[C:14]2[C:9](=[CH:8][CH:7]=[CH:6][C:5]=2[O:4][C:3]2[CH:15]=[CH:16][CH:17]=[CH:18][C:2]=2[NH:1][S:26]([C:23]2[CH:24]=[CH:25][C:20]([Cl:19])=[CH:21][CH:22]=2)(=[O:28])=[O:27])[CH:10]=[CH:11][CH:12]=1

Participants

5

Reactant 3

HCID 1049PyridineHCID 73984-Chlorobenzenesulfonyl chlorideHCID 14127593HCID 14127593, compound

Product 1

HCID 14127620HCID 14127620, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Conditions

Temperature
25 °C

Procedure

3.54 g of 8-(2-aminophenoxy)quinoline are dissolved in 70 ml of dichloromethane, and a solution of 3.17 g of 4-chlorobenzenesulphonyl chloride in 30 ml of dichloromethane is added at 25° C. After 1 hour, 2.42 ml of pyridine are added, and the mixture is stirred for 15 hours at 25° C. After removal of the solvent by evaporation, the residue is stirred with water. The product is filtered off and recrystallized from ethanol.

Workup

  1. customAfter removal of the solvent
  2. customby evaporation
  3. stirringthe residue is stirred with water
  4. filtrationThe product is filtered off
  5. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-8e4533b13085418abdfe82b663b55264
Source dataset
uspto-grants-1992_03
Patent number
US05093340

Reaction notes

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