Thionyl Chloride → HCID 556978, compound

HRID 2371434Notes

Reaction equation

HRID 2371434 reaction equation
[CH:1]1([CH3:15])[CH2:6][CH2:5][CH:4]([CH:7]([CH3:9])[CH3:8])[CH:3]([O:10][CH2:11][C:12](O)=[O:13])[CH2:2]1.S(Cl)([Cl:18])=O>>[CH:1]1([CH3:15])[CH2:6][CH2:5][CH:4]([CH:7]([CH3:9])[CH3:8])[CH:3]([O:10][CH2:11][C:12]([Cl:18])=[O:13])[CH2:2]1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 978142-((5-Methyl-2-(1-methylethyl)cyclohexyl)oxy)acetic acid

Product 1

HCID 556978HCID 556978, compoundYield 107.4%

Procedure

0.771 g (3.6 mmol) of (-)-menthoxyacetic acid is stirred under reflux with 2.1 g of thionyl chloride for 4 to 5 h. The thionyl chloride is first removed from the solution by distillation under reduced pressure. 3 ml of dry benzene are then added in order to remove residual thionyl chloride by means of vacuum distillation. 0.9 g of the title compound is obtained.

Workup

  1. customThe thionyl chloride is first removed from the solution by distillation under reduced pressure
  2. addition3 ml of dry benzene are then added in order
  3. customto remove residual thionyl chloride
  4. distillationby means of vacuum distillation

Sources & evidence

ORD record
ord-e451021af54e4d49b89adeba7e1e916b
Source dataset
uspto-grants-1992_03
Patent number
US05093350

Reaction notes

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