HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-(4-(3,5-Dichlorobenzamido) phenoxy)2-methylpropionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 3,5-Dichlorobenzoyl chloride | HCID 76191 | — |
| Reactant | 2-(4-Aminophenoxy)-2-methylpropanoic acid | HCID 2774958 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | 2-(4-(3,5-Dichlorobenzamido) phenoxy)2-methylpropionic acid | HCID 14545091 | 76% |
Reaction Steps
To a solution of 0.5 g 2-(4-aminophenoxy)-2-methylpropionic acid in 5 ml 2N NaOH, 0.70 ml 3,5-dichlorobenzoyl chloride was dropwise added with stirring 5 ml additional 2N NaOH was gradually added to keep the PH strongly alkaline during the reaction. After 1 hour stirring, the reaction product was acidified with HCl. The white precipitate was recrystallized from aqueous isopropanol to give 1.4 g (76%) of fine crystals MP 206°-207°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05093367 |
| Source dataset | uspto-grants-1992_03 |
| ORD ID | ord-f22e241782f44b80868162cdf2968315 |
| Source note | uspto-grants-1992_03 |