huagongshe.com
HRID2371463

反应详情

EQUATION

反应方程式

HRID 2371463 的结构方程式

REACTANTS

反应物

3
结构：Cl
HCID313

Hydrochloric Acid

ClH

结构：O=C(Cl)c1cc(Cl)cc(Cl)c1
HCID76191

3,5-Dichlorobenzoyl chloride

C7H3Cl3O

结构：CC(C)(Oc1ccc(N)cc1)C(=O)O
HCID2774958

2-(4-Aminophenoxy)-2-methylpropanoic acid

C10H13NO3

PRODUCTS

生成物

1
结构：CC(C)(Oc1ccc(NC(=O)c2cc(Cl)cc(Cl)c2)cc1)C(=O)O
HCID14545091

未命名化合物

收率 76%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：[Na+].[OH-]
溶剂HCID14798

Sodium Hydroxide

HNaO

2 次

PROCEDURE

实验过程

To a solution of 0.5 g 2-(4-aminophenoxy)-2-methylpropionic acid in 5 ml 2N NaOH, 0.70 ml 3,5-dichlorobenzoyl chloride was dropwise added with stirring 5 ml additional 2N NaOH was gradually added to keep the PH strongly alkaline during the reaction. After 1 hour stirring, the reaction product was acidified with HCl. The white precipitate was recrystallized from aqueous isopropanol to give 1.4 g (76%) of fine crystals MP 206°-207°.

WORKUP

后处理

  1. additionwas gradually added
  2. customstrongly alkaline during the reaction
  3. customThe white precipitate was recrystallized from aqueous isopropanol