Phthalic Anhydride → Phthalimidomethanesulfonic acid potassium salt

HRID 237148Notes

Reaction equation

HRID 237148 reaction equation
[NH2:1][CH2:2][S:3]([OH:6])(=[O:5])=[O:4].C([O-])(=O)C.[K+:11].[C:12]1(=O)[O:17][C:15](=[O:16])[C:14]2=[CH:18][CH:19]=[CH:20][CH:21]=[C:13]12>C(O)(=O)C>[K+:11].[C:12]1(=[O:17])[N:1]([CH2:2][S:3]([O-:6])(=[O:5])=[O:4])[C:15](=[O:16])[C:14]2=[CH:18][CH:19]=[CH:20][CH:21]=[C:13]12

Participants

5

Reactant 3

HCID 6811Phthalic AnhydrideHCID 83791Aminomethanesulfonic acidHCID 517044Potassium Acetate

Product 1

HCID 88789710Phthalimidomethanesulfonic acid potassium salt

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A suspension of 15.1 g. (0.136 mol.) of aminomethanesulfonic acid and 14.2 g. (0.145 mol.) of anhydrous potassium acetate in 48 ml. of acetic acid is refluxed for ten minutes. Phthalic anhydride (21.4 g., 0.145 mol.) is then added and the resulting mixture is refluxed for 2.5 hours. The product is collected by filtration and washed with acetic acid and ethanol to give phthalimidomethanesulfonic acid potassium salt.

Workup

  1. additionA suspension of 15.1 g
  2. temperaturethe resulting mixture is refluxed for 2.5 hours
  3. filtrationThe product is collected by filtration
  4. washwashed with acetic acid and ethanol

Sources & evidence

ORD record
ord-3ad878db3ec344a08ab140c2495a69e3
Source dataset
uspto-grants-1979_06
Patent number
US04159373

Reaction notes

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