1-Methyl-1,2-dihydropyridine → HCID 86745532, compound

HRID 2371523Notes

Reaction equation

HRID 2371523 reaction equation
[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][CH2:14][CH2:15][CH2:16][CH2:17]Br)=[CH:9][CH:8]=1.[CH3:19][N:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH2:21]1>C(O)C>[Br-:1].[Br-:1].[CH3:19][N+:20]1([CH:16]([CH3:17])[CH2:15][CH2:14][CH2:13][C:10]2[CH:9]=[CH:8][CH:7]=[CH:12][CH:11]=2)[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1.[CH3:19][N+:20]1([CH:3]([CH3:2])[CH2:4][CH2:5][CH2:6][C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25]1

Participants

4

Reactant 2

HCID 125655021-Methyl-1,2-dihydropyridineHCID 19907362HCID 19907362, compound

Product 1

HCID 86745532HCID 86745532, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 376 mg of 1,4-bis(5-bromopentyl)benzene in 2 ml of absolute ethanol, 365 μl of N-methylpyridine was added, and the mixture was refluxed for 5 hours. After concentration under a reduced pressure and addition of acetone, and the mixture was allowed to stand overnight. The product was filtered and recrystallized from ethanol (0.5 ml)--acetone (2 ml) to obtain 455 mg of the title compound as a colorless crystal.

Workup

  1. temperaturethe mixture was refluxed for 5 hours
  2. concentrationAfter concentration
  3. additionunder a reduced pressure and addition of acetone
  4. filtrationThe product was filtered
  5. customrecrystallized from ethanol (0.5 ml)

Sources & evidence

ORD record
ord-9ce773c66a6f42c5b3f942e546aec926
Source dataset
uspto-grants-1992_03
Patent number
US05093370

Reaction notes

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