2-Chloroethanol → HCID 19907383, compound

HRID 2371524Notes

Reaction equation

HRID 2371524 reaction equation
[C:1]1([CH2:9]Cl)[CH:6]=[CH:5][C:4]([CH2:7]Cl)=[CH:3][CH:2]=1.[Cl:11][CH2:12][CH2:13][OH:14]>>[Cl:11][CH2:12][CH2:13][O:14][CH2:9][C:1]1[CH:2]=[CH:3][C:4]([CH2:7][O:14][CH2:13][CH2:12][Cl:11])=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 342-Chloroethanol2×HCID 12171alpha,alpha'-Dichloro-p-xylene

Product 1

HCID 19907383HCID 19907383, compound

Procedure

To 5.0 g of p-xylylene dichloride was added 25 ml of 2-chloroethanol, and the mixture was refluxed for 24 hours. After the reaction, 2-chloroethanol was removed under reduce pressure at 100° C. The residue was applied to a silica gel column and eluted with hexane/chloroform (1:1) as eluent, and a relevant fraction was further purified by distillation to obtain 2.44 g of the title compound as a colorless liquid.

Workup

  1. temperaturethe mixture was refluxed for 24 hours
  2. customwas removed
  3. customat 100° C
  4. washeluted with hexane/chloroform (1:1) as eluent
  5. distillationa relevant fraction was further purified by distillation

Sources & evidence

ORD record
ord-dc37ad41c37246ca82c1cd4b24a30c85
Source dataset
uspto-grants-1992_03
Patent number
US05093370

Reaction notes

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