Hydrochloric Acid → HCID 19907380, compound

Participants

Reaction Steps

To a solution of, 822 mg of 1,3-bis[4-(2-tetrahydropyranyloxy)butyl]benzene in 3 ml of ethanol was added 1.5 ml of 6N hydrochloric acid, and after stirring at a room temperature for 7 hours, 30 ml of ethyl acetate and 10 ml of ice water were added. The separated organic layer was washed with 5% sodium bicarbonate aqueous solution, water and a saturated sodium chloride, dried over magnesium sulfate, and evaporated under a reduced pressure to remove the solvent. The resulting oily residue was applied to a silica gel column and eluted with chloroform/methanol (100:1) to obtain 264 mg of the title compound as a colorless liquid.

Provenance & Evidence