Hydrochloric Acid → HCID 19907380, 화합물

HRID 2371534노트

반응식

HRID 2371534 반응식
O1CCCCC1[O:7][CH2:8][CH2:9][CH2:10][CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([CH2:18][CH2:19][CH2:20][CH2:21][O:22]C2CCCCO2)[CH:13]=1.Cl.C(OCC)(=O)C>C(O)C>[OH:7][CH2:8][CH2:9][CH2:10][CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([CH2:18][CH2:19][CH2:20][CH2:21][OH:22])[CH:13]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 19907429HCID 19907429, 화합물

생성물 1

HCID 19907380HCID 19907380, 화합물수율 56.4%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of, 822 mg of 1,3-bis[4-(2-tetrahydropyranyloxy)butyl]benzene in 3 ml of ethanol was added 1.5 ml of 6N hydrochloric acid, and after stirring at a room temperature for 7 hours, 30 ml of ethyl acetate and 10 ml of ice water were added. The separated organic layer was washed with 5% sodium bicarbonate aqueous solution, water and a saturated sodium chloride, dried over magnesium sulfate, and evaporated under a reduced pressure to remove the solvent. The resulting oily residue was applied to a silica gel column and eluted with chloroform/methanol (100:1) to obtain 264 mg of the title compound as a colorless liquid.

후처리

  1. washThe separated organic layer was washed with 5% sodium bicarbonate aqueous solution, water
  2. dry with materiala saturated sodium chloride, dried over magnesium sulfate
  3. customevaporated under a reduced pressure
  4. customto remove the solvent
  5. washeluted with chloroform/methanol (100:1)

출처 및 근거

ORD 기록
ord-ee401d47fbce438698e1f61aee1ea35b
출처 데이터셋
uspto-grants-1992_03
특허 번호
US05093370

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