Nitric acid,thallium(3+) salt, trihydrate (9CI) → HCID 19907374, compound

First, 695 mg of 2,2'-ethylenebis[2-(3-dimethylaminopropyl)-m-dithian] was dissolved in 24 ml of absolute methanol and 6 ml of absolute tetrahydrofuran, and after adding dropwise a solution of 3.12 g of thallium (III) nitrate trihydrate in 18 ml of absolute methanol over 2 minutes while stirring at a room temperature, the mixture was stirred for 30 minutes, filtered to remove insoluble matter, and evaporated under a reduced pressure to remove the solvent. After adding 30 ml of water, the mixture was extracted with 100 ml and 50 ml of chloroform. The extracts were combined, washed with a saturated sodium chloride aqueous solution, dried over magnesium sulfate, filtered, and evaporated under a reduced pressure. The residue was applied to a silica gel column and eluted with chloroform/methanol/triethylamine (80:20:1) to obtain 178 mg of the title compound as a pale yellow liquid.

1. stirringthe mixture was stirred for 30 minutes
2. filtrationfiltered
3. customto remove insoluble matter
4. customevaporated under a reduced pressure
5. customto remove the solvent
6. additionAfter adding 30 ml of water
7. extractionthe mixture was extracted with 100 ml and 50 ml of chloroform
8. washwashed with a saturated sodium chloride aqueous solution
9. dry with materialdried over magnesium sulfate
10. filtrationfiltered
11. customevaporated under a reduced pressure
12. washeluted with chloroform/methanol/triethylamine (80:20:1)

ORD record

ord-9c8d4cc2be6e47528ffd8fe68d776733

Source dataset

uspto-grants-1992_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05093370