Potassium Fluoride → 2-Chloro-4,5-difluorobenzoyl fluoride

HRID 2371575Notes

Reaction equation

HRID 2371575 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]([F:11])[C:8]([F:12])=[CH:7][C:3]=1[C:4](Cl)=[O:5].[F-:13].[K+]>>[Cl:1][C:2]1[CH:10]=[C:9]([F:11])[C:8]([F:12])=[CH:7][C:3]=1[C:4]([F:13])=[O:5]

Participants

3

Reactant 2

HCID 522689Potassium FluorideHCID 101982172-Chloro-4,5-difluorobenzoyl chloride

Product 1

HCID 147961732-Chloro-4,5-difluorobenzoyl fluoride

Procedure

Into a 200 cc glass reactor equipped with a reflux condenser, 50 g of 2-chloro-4,5-difluorobenzoylchloride, 13.7 g of spray dried potassium fluoride and 100 g of sulforane were charged and reacted at 135° C. for 4 hours under stirring. After cooling, the inorganic salts were filtered off, and the residue was subjected to distillation under reduced pressure to obtain 42 g of 2-chloro-4,5-difluorobenzoyl fluoride. The physical properties of the obtained 2-choloro 4,5-difluorobenzoyl fluoride were as follows.

Workup

  1. customInto a 200 cc glass reactor equipped with a reflux condenser
  2. customreacted at 135° C. for 4 hours
  3. temperatureAfter cooling
  4. filtrationthe inorganic salts were filtered off
  5. distillationthe residue was subjected to distillation under reduced pressure

Sources & evidence

ORD record
ord-dbfc05c0624a493aa5cacf44e491ebd9
Source dataset
uspto-grants-1992_03
Patent number
US05093515

Reaction notes

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