Dichloromethane → 3,4-dihydro-4-oxo-7-(phenylmethoxy)-8-propyl-2H-1-benzopyran-2,2-dipropanoic acid

HRID 2371618Notes

Reaction equation

HRID 2371618 reaction equation
[O:1]=[C:2]1[C:7]2[CH:8]=[CH:9][C:10]([O:15][CH2:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)=[C:11]([CH2:12][CH2:13][CH3:14])[C:6]=2[O:5][C:4]([CH2:29][CH2:30][C:31]([O:33]C)=[O:32])([CH2:23][CH2:24][C:25]([O:27]C)=[O:26])[CH2:3]1.ClC1C=CC(OCCCOC2C=CC3C(=O)CC(CCC(OCC)=O)(CCC(OCC)=O)OC=3C=2CCC)=CC=1.C(Cl)Cl>C(OCC)(=O)C>[O:1]=[C:2]1[C:7]2[CH:8]=[CH:9][C:10]([O:15][CH2:16][C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=3)=[C:11]([CH2:12][CH2:13][CH3:14])[C:6]=2[O:5][C:4]([CH2:23][CH2:24][C:25]([OH:27])=[O:26])([CH2:29][CH2:30][C:31]([OH:33])=[O:32])[CH2:3]1

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 15157435dimethyl 3,4-dihydro-4-oxo-7-(phenylmethoxy)-8-propyl-2H-1-benzopyran-2,2-dipropanoateHCID 15157438diethyl 3,4-dihydro-7-[3-(4-chlorophenoxy)propoxy]-4-oxo-8-propyl-2H-1-benzopyran-2,2-dipropanoate

Product 1

HCID 151574423,4-dihydro-4-oxo-7-(phenylmethoxy)-8-propyl-2H-1-benzopyran-2,2-dipropanoic acid

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

The title compound, 102 mg, m.p. 202°-205° C., was prepared by the method of Example 22 substituting the title product of Example 18 (455 mg) for the title product of Example 21, and utilizing methylene chloride as the extraction solvent instead of ethyl acetate.

Sources & evidence

ORD record
ord-4f685af29dc2443e9909d0609a66881c
Source dataset
uspto-grants-1992_03
Patent number
US05093353

Reaction notes

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