HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile → 3-((((1,1-Dimethylethoxy)carbonyl)amino)methyl)benzeneacetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile | HCID 93865 | — |
| Reactant | [3-(Aminomethyl)phenyl]acetic acid hydrochloride | HCID 45263723 | — |
| Reactant | (4-(Aminomethyl)phenyl)acetic acid--hydrogen chloride (1/1) | HCID 53407881 | — |
| Product | 3-((((1,1-Dimethylethoxy)carbonyl)amino)methyl)benzeneacetic acid | HCID 2755930 | — |
Reaction Steps
Substitution of an equivalent amount of 3-aminomethylphenylacetic acid hydrochloride for 4-aminomethylphenylacetic acid hydrochloride in the reaction with 2-t-butoxycarbonyloxyimino-2-phenylacetonitrile described in Example 54 gave 3-(N-t-butoxycarbonylaminomethyl)phenylacetic acid, m.p. 95°-96.5°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04159373 |
| Source dataset | uspto-grants-1979_06 |
| ORD ID | ord-fc8303e40bc84aa2b79d13d2c6104f0e |
| Source note | uspto-grants-1979_06 |