反应详情

温度

0 °C

A solution of 202 mg (1.05 mmol) of the title product of Example 59 in 10 ml of CH2Cl2 was cooled with stirring to 0° C. and treated sequentially with 370 mg (3.70 mmol) of triethylamine and 362 mg (3.15 mmol) of methanesulfonyl chloride. After one hour, the mixture was treated with another 370 mg of triethylamine and 362 mg of methanesulfonyl chloride. After one-half hour, the mixture was washed successively with water, aqueous sodium bicarbonate solution, dilute aqueous hydrochloric acid, and water. The organic phase was dried (MgSO4), filtered, and the solvent removed under reduced pressure. The residue was taken up in 10 ml of dimethylformamide. To the resulting solution was added 406 mg (1.00 mmol) of the title product of Example 1 and 290 mg (2.10 mmol) of anhydrous potassium carbonate. The mixture was stirred overnight at room temperature. Another 290 mg of potassium carbonate was then added, and stirring was continued at 60° C. for six hours. The mixture was allowed to cool, and the solvent was removed under reduced pressure. The residue was partitioned between ethyl acetate and water. The aqueous layer was further extracted with two portions of ethyl acetate. The combined organic extracts were washed successively with water and with brine, dried (Na2SO4), filtered, and the solvent removed under reduced pressure. The residue was chromatographed over silica gel. Elution with 15% ethyl acetate/toluene produced 152 mg of the title compound as a solid.

1. waitAfter one-half hour
2. washthe mixture was washed successively with water, aqueous sodium bicarbonate solution, dilute aqueous hydrochloric acid, and water
3. dry with materialThe organic phase was dried (MgSO4)
4. filtrationfiltered
5. customthe solvent removed under reduced pressure
6. stirringThe mixture was stirred overnight at room temperature
7. stirringstirring
8. waitwas continued at 60° C. for six hours
9. temperatureto cool
10. customthe solvent was removed under reduced pressure
11. customThe residue was partitioned between ethyl acetate and water
12. extractionThe aqueous layer was further extracted with two portions of ethyl acetate
13. washThe combined organic extracts were washed successively with water and with brine
14. dry with materialdried (Na2SO4)
15. filtrationfiltered
16. customthe solvent removed under reduced pressure
17. customThe residue was chromatographed over silica gel
18. washElution with 15% ethyl acetate/toluene