Sodium Hydroxide → HCID 67914037, compound

HRID 2371714Notes

Reaction equation

HRID 2371714 reaction equation
[ClH:1].[CH:2]1[C:12]2[C:11](=[C:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][CH2:21][CH2:22][C:23]([O:25]CC)=[O:24])[CH2:15][CH2:14]3)[C:10]3[CH:28]=[CH:29][CH:30]=[CH:31][C:9]=3[CH2:8][O:7][C:6]=2[CH:5]=[CH:4][CH:3]=1.[OH-].[Na+]>CO>[ClH:1].[CH:2]1[C:12]2[C:11](=[C:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][CH2:21][CH2:22][C:23]([OH:25])=[O:24])[CH2:15][CH2:14]3)[C:10]3[CH:28]=[CH:29][CH:30]=[CH:31][C:9]=3[CH2:8][O:7][C:6]=2[CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 19906317HCID 19906317, compound

Product 1

HCID 67914037HCID 67914037, compoundYield 99.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 4.20 g of ethyl 4-(dibenz[b,e]oxepin-11(6H)-ylidene)-1-piperidinevalerate hydrochloride, 14.5 ml of 2N sodium hydroxide aqueous solution and 40 ml of methanol was refluxed for 1 hr and concentrated. Water was added to the residue, adjusted to pH 2 with 10% hydrochloric acid. The precipitate was collected by filtration and washed with water and ether to give 3.92 g of colorless crystals, which were recrystallized from water to give 3.08 g of colorless prisms, mp 304°-306° C. (dec.).

Workup

  1. temperaturewas refluxed for 1 hr
  2. concentrationconcentrated
  3. additionWater was added to the residue
  4. filtrationThe precipitate was collected by filtration
  5. washwashed with water and ether

Sources & evidence

ORD record
ord-3790930e6f5342a58bf5dbaff273c29e
Source dataset
uspto-grants-1992_03
Patent number
US05095022

Reaction notes

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