Hydrochloric Acid → HCID 12641338, compound

Temperature

-78 °C

To a solution of 2.0 g (13 mmol) of (4a alpha, 8a alpha)(rac)-octahydro-3H-2-benzopyran-3-one in 65 mL of dry dichloromethane was added dropwise, over 30 min, 14 mL (14.3 mmol) of a 1.0 M solution of diisobutylaluminum hydride in dichloromethane. After further stirring at -78° C. for 45 min the mixture was warmed to 0° C. over 2 hours, stirred at 0° C. for 10 min, and then 1.0M aqueous HCl was added dropwise until a pH 0-1 was reached. After addition of 60 mL of ether, phase separation and extraction of the aqueous portion with 3×50 mL of ether, the combined organic solutions were washed with 5% KHCO3, dried (MgSO4) and concentrated under vacuum to 1.60 g (80%) of racemic (4a alpha, 8a alpha)-octahydro-1H-2-benzopyran-3-ol. TLC Rf 0.41 (SiO2, ether, molybdophosphoric acid-blue).

1. temperaturewas warmed to 0° C. over 2 hours
2. stirringstirred at 0° C. for 10 min
3. washthe combined organic solutions were washed with 5% KHCO3
4. dry with materialdried (MgSO4)
5. concentrationconcentrated under vacuum to 1.60 g (80%) of racemic (4a alpha, 8a alpha)-octahydro-1H-2-benzopyran-3-ol

ORD record

ord-1aa034e578a0461d9d2169643a01c6f4

Source dataset

uspto-grants-1992_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05095109