Triethylsilane → (E)-3-[(2S,4S)-N-Allyloxycarbonyl-4-mercaptopyrrolidin-2-yl]-N-methylacrylamide

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Reaction Steps

The same operation as in Reference Example 4-2) was carried out by using (E)-3-[(2S,4S)-N-allyloxycarbonyl-4-tritylthiopyrrolidin-2-yl]-N-methylacrylamide (the compound obtained in Reference Example 5-1); 1.54 g, 3 mmol) and triethylsilane (0.49 ml, 3.15 mmol), followed by flash column chromatographic purification on silica gel (Wakogel® C-300, 40 ml, elution with acetone-methylene chloride 1:1) to give the title compound (620 mg, 76.3% yield).

Provenance & Evidence