反应详情

The same operation as in Reference Example 4-2) was carried out by using (E)-3-[(2S,4S)-N-allyloxycarbonyl-4-tritylthiopyrrolidin-2-yl]-N-methylacrylamide (the compound obtained in Reference Example 5-1); 1.54 g, 3 mmol) and triethylsilane (0.49 ml, 3.15 mmol), followed by flash column chromatographic purification on silica gel (Wakogel® C-300, 40 ml, elution with acetone-methylene chloride 1:1) to give the title compound (620 mg, 76.3% yield).

1. customobtained in Reference Example 5-1)