Thiazolidine → HCID 19905280, compound

Participants

Reaction Conditions

Reaction Steps

A solution containing 8.43 g (0.05 mol) of β-chloropropiophenone, 4.10 g (0.05 mol) of anhydrous sodium acetate and 4.01 g (0.045 mol) of thiazolidine in 30 ml of ethanol is stirred at 25° C. for 8 hours. After filtering off the precipitate and evaporating the solvent from the solution, the oily yellowish residue weighing 9.3 g is converted to the hydrochloride in a mixture of acetone and ether in the usual way to give 9.9 g of product. After recrystallization from methanol, the hydrochloride of the title product thus obtained melts at 170°-171° C.; it is identical to the hydrochloride described in Examples 1 and 43.

Provenance & Evidence