反应详情

温度

60 °C

A mixture of 2.85 g (10.3 mmol) of 6-(4-carboethoxymethoxyphenyl)-4,5-dihydro-3(2H)-pyridazinone (prepared as described in Example 13) and 9.3 g (155 mmol) of ethylenediamine is heated at 60° C. under N2 for 30 min. Volatile materials are removed in vacuo, and the residue is recrystallized from methanol-EtOAc to give 2.40 g of 6-[4-[2-aminoethylcarbamoylmethoxy]phenyl]-4,5-dihydro-3(2H)-pyridazinone as a white solid, m.p. 176°-177.5° C. Yield, 80%.

1. customVolatile materials are removed in vacuo
2. customthe residue is recrystallized from methanol-EtOAc